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Doege–Potter syndrome
Doege–Potter syndrome (DPS) is a paraneoplastic syndrome in which hypoglycemia is associated with solitary fibrous tumors. The hypoglycemia is the result of the tumors producing insulin-like growth factor 2. The syndrome was first described in 1930, by Doege and Potter working independently; the full term "Doege–Potter syndrome" was infrequently used until the publication of a 2000 article using the eponym.
DPS is rare (as of 1976, less than one hundred cases were described), with a malignancy rate of 12–15%. Actual rates of hypoglycemia associated with a fibrous tumor are quite rare (a 1981 study of 360 solitary fibrous tumors of the lungs found that only 4% caused hypoglycemia), and are linked to large tumours with high rates of mitosis. Removal of the tumor will normally resolve the symptoms.〔〔
Tumors causing DPS tend to be quite large; in one case a , mass was removed, sufficiently large to cause a collapsed lung.〔 In X-rays, they appear as a single mass with visible, defined borders, appearing at the edges of the lungs or a fissure dividing the lobes of the lungs.〔 Similar hypoglycemic effects have been related to mesenchymal tumors.〔
==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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